Current Rheumatology Diagnosis and Treatment by John B. Imboden

By John B. Imboden

This can be the main up to date and without problems obtainable rheumatology source to be had. The 3rd variation of this depended on quick-reference advisor has every thing you must retain velocity with this fast-moving field-presented within the acclaimed present layout. a realistic reference for fundamental care prone, the booklet simplifies the remedy of difficult-to-manage rheumatologic ailments and problems, corresponding to arthritis, lupus, and sarcoidosis. positive factors: new full-color pictures; new chapters on medical genetics, drug-induced syndromes, and metabolic myopathies; simple, specialist insurance of the total variety of rheumatology problems; complete factors of universal and significant problems in scientific immunology; concise chapters geared to the wishes of trainees and clinicians; and primary part that addresses universal yet difficult-to-diagnose rheumatologic lawsuits - and provides key "approach to the sufferer" thoughts.

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Type II cryoglobulins are immune complexes composed of a monoclonal immunoglobulin (usually IgM) with rheumatoid factor activity and polyclonal IgG. Most cases of type II cryoglobulinemia are associated with chronic hepatitis C infection and manifest clinically as an immune complex-mediated vasculitis with palpable purpura (see Chapter 44). The levels of C4 are usually low. Tests for serum rheumatoid factor are positive unless handling of the sample at lower than 37°C produces a false-negative test.

However, it should be kept in mind that the combination of arthritis and a positive test for rheumatoid factor is not specific for rheumatoid arthritis and can be seen in patients with systemic lupus erythematosus (SLE), mixed connective tissue disease, systemic vasculitis, polymyositis, dermatomyositis, sarcoidosis, subacute bacterial endocarditis, and viral infections, particularly hepatitis C. 33 34 A negative test for rheumatoid factor should not be the only reason to rule out the possibility of rheumatoid arthritis.

2001;344:1140, 1058. [PMID: 11297706] Walport MJ. Complement. N Engl J Med. 2001;344:1140, 1058. [PMID: 11297706] [PMID: 11287977] Wener MH, Hutchinson K, Morishima C, Gretch DR. Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia Arthritis Rheum. 2004;50:2305-2308. [PMID: 15248231] Copyright ©2007 The McGraw-Hill Companies. All rights reserved. Privacy Notice. Any use is subject to the Terms of Use and Notice. Additional Credits and Copyright Information.

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