Copper and the Skin by Jurij J. Hostynek, Howard I. Maibach
By Jurij J. Hostynek, Howard I. Maibach
Copper is more and more famous for its attainable position within the prevention and moderation of disorder, in addition to the remedy of a couple of stipulations together with dermis inflammation, sensitization, rheumatoid arthritis, and different inflammatory stipulations. This resource stories normal rules of percutaneous penetration to elucidate the mechanisms controlling anti inflammatory job, dermal sensitivity, and the absorption of copper compounds within the human physique and the results of those features on fit pores and skin and human healthiness.
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Extra resources for Copper and the Skin
Transported by blood throughout the organism, copper, in particular, will be sequestered by metallothionein (MT) or coeruloplasmin, and deposited in various organs and tissues (76). In order to discuss the phenomenon of skin penetration by metal compounds as ionized salts, complexes, or organometallic compounds, and to correctly interpret the meaning of experimental results and clinical observations attributed to the action of metals, it is important to visualize the structure and function of the skin as a membrane, which can act as barrier, ﬁlter, reservoir, or an outright port of entry, and the microenvironment prevailing on its surface.
Set in relation to the corresponding in vivo data, the predictive power of these models, known as quantitative structure–activity relationships (or QSAR), demonstrates that (i) three descriptors (size, polarity, and hydrogen bonding) are the principal determinants for cutaneous transport, and (ii) the properties of the intercellular SC lipids alone are sufﬁcient to characterize the barrier properties of the skin as the route of permeation for that category of chemical structures (32). Rougier et al.
50. Beveridge SJ, Whitehouse MW, Walker WR. Lipophilic copper(II) formulations: some correlations between their composition and anti-inﬂammatory/ anti-arthritic activity when applied to the skin of rats. Agents Actions 1982; 12: 225–231. 51. Odintsova NA. Permeability of human skin to potassium and copper ions and their ultrastructural localization. Chem Abs 1978; 89:360. 52. Walker WR, Reeves RR, Brosnan M, Coleman GD. Perfusion of intact skin by a saline solution of bis(glycinato) copper(II).