Comprehensive Clinical Hepatology by Bruce R. Bacon MD, John G. O'Grady MD FRCPI, Adrian M.

By Bruce R. Bacon MD, John G. O'Grady MD FRCPI, Adrian M. DiBisceglie MD, John R. Lake MD

Authoritative and hugely illustrated in complete colour, this complete source is the results of a joint attempt of 4 skilled senior clinicians and educators. It makes a speciality of the scientific facets of transplantation, deals an oasis of data on key subject matters for medical perform and exam, and discusses the most recent advancements within the box, together with NASH and protracted viral hepatitis.

  • Covers all elements of clinical transplantation.
  • Features professional tips and medical assurance in a single handy volume.
  • Uses full-color artwork, scientific photos, and time-saving tables for simple retrieval of information.
  • Emphasizes key issues for medical perform and certifying examinations.
  • Incorporates the newest advances in Hepatology, together with NASH and protracted viral hepatitis.
  • Features an advantage CD-ROM containing the entire excellent full-color illustrations from the booklet in a position to be downloaded into PowerPoint™.

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Example text

6 Cell surface receptors in normal liver. Cl, cation-independent; ASGP, asialoglycoprotein; LDL, low-density lipoprotein; EGF, epidermal growth factor; GlcNAc, N-acetylglucosamine; M6P, mannose 6-phosphate. ponsive to many different ligands (Fig. 15). In general, there are three main families of cell-surface receptors, each of which transduces extracellular signals in a different way. Ion-channellinked receptors open or close briefly in response to their respective stimuli. G-protein-linked receptors indirectly activate or inactivate plasma-membrane-bound enzymes or ion channels via trimeric GTP-binding proteins (G-proteins).

In contrast, the smooth ER has no ribosomes and functions in lipid biosynthesis, detoxification and calcium regulation. RER commonly extends into large, flattened sacs called cisternae. Smooth ER membranes form primarily tubular sacs that are generally smaller in dimension than RER cisternae. At some points the smooth ER and RER membranes may connect, forming a continuous inner channel enclosed by both systems. In addition to the RER and smooth ER, there are at least four other morphologically distinct domains of the ER, including the nuclear envelope, transitional elements, crystalloid ER and luminal ER bodies containing protein aggregates.

The outer membrane, which faces the cytoplasm, is covered with ribosomes on its cytoplasmic side, and at certain points is continuous with the ER. The inner membrane, which faces the nucleoplasm, has no ribosomes. A fibrous nuclear Cellular Biology of the Normal Liver Chapter 2 lamina of intermediate filaments supports the inner nuclear membrane and mediates its interactions with chromatin. The outer and inner nuclear membranes enclose a narrow space about 40 nm wide, the perinuclear compartment.

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