Clinical Trials in Rheumatology by Ruediger Mueller, Johannes von Kempis
By Ruediger Mueller, Johannes von Kempis
A large variety of healing experiences has been released in rheumatology and medical immunology. This quantity grows considerably through the yr. As such, it turns into more and more tough to maintain music of this multitude of reports and the resultant healing developments. additional to this, a specific learn may be observed in quite a few methods, both as a shortened model of the identify or an acronym, including to the confusion. The booklet scientific Trials in Rheumatology offers a precis of the real reviews within the box for simple reference. each examine is proven with identify, acronym (if in existence), authors, entire quotation, examine layout, effects, and precis. An acronym finder is equipped firstly of the ebook. This e-book is a important reference device for rheumatologists and different scientific specialties, in addition to for learn scientists drawn to immunomodulatory and chosen different drug cures in rheumatologic illnesses.
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Adverse ocular events were dose independent Patients 212 early RA patients Stabilized with 1,000 mg naproxen/day ³ 6 tender joints ³ 3 swollen joints Erythrocyte sedimentation rate ³ 28 mm/h Morning stiffness ³ 1 hour Authors Furst DE, Lindsley H, Baethge B, Botstein GR, Caldwell J, Dietz F, Ettlinger R, Golden HE, McLaughlin GE, Moreland LW, Roberts WN, Rooney TW, Rothschild B, Sack M, Sebba AI, Weisman M, Welch KE, Yocum D Publication Arthritis Rheum. 5 (HCQ 1200) Adverse events Body as a whole n = 12 (HCQ 400), n = 14 (HCQ 800), n = 7 (HCQ 1200) Central nervous system n = 6 (HCQ 400), n = 12 (HCQ 800), n = 4 (HCQ 1200) Headache n = 1 (HCQ 400), n = 8 (HCQ 800), n = 3 (HCQ 1200) Gastrointestinal n = 19 (HCQ 400), n = 12 (HCQ 800), n = 13 (HCQ 1200) Nausea, vomiting n = 9 (HCQ 400), n = 8 (HCQ 800), n = 7 (HCQ 1200) Hearing n = 2 (HCQ 400), n = 0 (HCQ 800), n = 3 (HCQ 1200) Psychiatric n = 2 (HCQ 400), n = 3 (HCQ 800), n = 0 (HCQ 1200) Respiratory n = 11 (HCQ 400), n = 10 (HCQ 800), n = 11 (HCQ 1200) Skin n = 6 (HCQ 400), n = 6 (HCQ 800), n = 8 (HCQ 1200) Vision n = 5 (HCQ 400), n = 4 (HCQ 800), n = 1 (HCQ 1200) 22 Rheumatoid Arthritis: Hydroxychloroquine HERA-Trial Consequences of delayed therapy with second-line agents in rheumatoid arthritis: a 3 year follow-up on the Hydroxychloroquine in early rheumatoid arthritis (HERA) study HERA: Hydroxychloroquine in early rheumatoid arthritis Substance Hydroxychloroquine 7 mg/kg per day (max.
Depomedrone. It was associated with a small reduction in bone erosion at the cost of a significant increase in adverse events Patients 91 RA patients Disease duration 2–10 years ³ 1 Erosion on plain X ray examination of the hands, wrists, and feet Continuous stable DMARD treatment ³ 3 months Active disease > 6 swollen joints Erythrocyte sedimentation rate >30 mm/h Authors Choy EH, Kingsley GH, Khoshaba B, Pipitone N, Scott DL; Intramuscular Methylprednisolone Study Group Publication Ann Rheum Dis.
883 Follow up 32 weeks Note Morning stiffness improved 41% (15 mg), 76% (150 mg) Grip strength improved 43% (15 mg), 70% (150 mg) No. of painful joints improved 43% (15 mg), 90% (150 mg) No. of swollen joints improved 46% (15 mg), 85% (150 mg) 50 m foot walk improved 38% (15 mg), 83% (150 mg) ESR improved 54% (15 mg), 44% (150 mg) Adverse events Hemorrhagic cystitis n = 0 (15 mg), n = 2 (150 mg) Dysuria without hematuria n = 0 (15 mg), n = 7 (150 mg) Herpes zoster n = 0 (15 mg), n = 1 (150 mg) Nausea and vomiting n = 9 (15 mg), n = 9 (150 mg) Diarrhoea n = 4 (15 mg), n = 3 (150 mg) Major hair loss n = 2 (15 mg), n = 7 (150 mg) Rheumatoid Arthritis: Cyclophosphamide Trial Arthritis Rheum.