Biologics for the Treatment of Rheumatoid Arthritis by Ronald van Vollenhoven

By Ronald van Vollenhoven

This ebook presents a accomplished review of the to be had biologic remedies when evaluating them to straightforward sickness editing anti-rheumatic medicinal drugs, and discusses how top to figure out which remedy is best for somebody sufferer within the framework of present directions. Biologics for the therapy of Rheumatoid Arthritis is an updated and concise useful consultant to the newest healing advancements during this box. This booklet is a useful resource of topical details for all rheumatologists and overall healthiness care execs treating sufferers with rheumatoid arthritis.

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1996;35:231-240. Reinhart K, Wiegand-Lohnert C, Grimminger F, et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med. 1996;24:733-742. Cohen J, Carlet J. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group.

However, because the latter are based on Phase III clinical trials they are often not very relevant for clinical practice, being either too general to be useful (‘approved for patients with active disease’) or too vague (‘having failed other therapies’). Thus, many professional organizations have published guidelines on the use of biologics, and these have also been revised on several occasions. Moreover, health care payers are increasingly determining the uses of medications that can be reimbursed.

1). In addition, a small-molecular agent with biologic-like effects has been approved in the US (and many other countries around world), an anti-TNF biosimilar has been approved in Europe, and additional biologics are in late-stage development for RA. 1. They differ in structure, half-life, route of administration (intravenous or subcutaneous), dose, frequency, and in some practical aspects, but they are remarkably similar in both efficacy and safety. National and international recommendations and guidance documents generally treat these medications as a single group.

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