Atlas of Pancreatic Cytopathology: With Histopathologic by Syed Z. Ali MD, Yener S. Erozan MD, Ralph H. Hruban MD

By Syed Z. Ali MD, Yener S. Erozan MD, Ralph H. Hruban MD

Scientific and radiologic examinations can't reliably distinguish benign or inflammatory pancreatic ailment from carcinoma. The elevated use of pancreatic effective needle aspiration (FNA) in addition to advances in imaging strategies and the advent of endoscopic ultrasound advice have ended in much better detection and popularity of pancreatic plenty. as a result, pancreatic cytopathology is quintessential to exact pre-operative prognosis but it's a tough diagnostic zone with quite a few strength pitfalls and "look-alike" lesions. Skillful acceptance and an understanding of the restrictions of the process are crucial in fending off misdiagnosis of those risky lesions.

Atlas of Pancreatic Cytopathology with Histopathologic Correlations fills a void in present pathology literature. With 450 high-resolution photographs, together with photographs of histopathologic and radiologic positive factors, this useful atlas offers an built-in method of diagnostic cytopathology that may aid health practitioner cytopathologists, cytotechnologists, and pathologists keep away from power pitfalls and "look-alike" lesions. Written by way of well-known specialists within the box, the huge high-resolution colour photographs of the attribute gains of pancreatic affliction are awarded with specified descriptions that hide vintage beneficial properties, diagnostic clues, and capability pitfalls.

Atlas of Pancreatic Cytopathology with Histopathologic Correlations is a priceless source for the pro cytopathologist, normal and surgical pathologists, pathology trainees, and cytotechnologists.

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Extra resources for Atlas of Pancreatic Cytopathology: With Histopathologic Correlations

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This hypocellular specimen is composed of rare small epithelial tissue fragments in a background showing degenerated adipose tissue and cellular debris. Microcalcifications are often seen in such cases in the cytologic smears. Despite the lack of cellular material, this picture strongly suggests chronic pancreatitis with associated fat necrosis. 5 — Chronic pancreatitis. Inflammatory cells with predominance of lymphocytes, display nuclear crush artifact. The cytopathologic appearance is non-specific and chronic pancreatitis is often a diagnosis of exclusion.

Large PENs tend to outgrow their blood supply and have a more heterogeneous pattern of enhancement. Central areas of necrosis and calcifications are not uncommon. Pancreatic Lymphoma Although lymphoma—predominantly the nonHodgkin B-cell type—can involve peripancreatic lymph nodes and secondarily spread to the pancreas, primary lymphoma of the pancreas is uncommon. At CT, pancreatic or peripancreatic lymphoma appear as solitary or multiple hypodense masses or 15 diffuse enlargement of the gland mimicking pancreatitis.

Note the clean smear background. 10 — Chronic pancreatitis. Cells with significant epithelial atypia are present. They have disorganized and enlarged nuclei, which appear hyperchromatic, forming three-dimensional structures. The changes are not enough to justify an “atypical” or “suspicious” interpretation. 11 — Chronic pancreatitis. Numerous fragments of glandular epithelium, fibrous tissue, and marked background chronic inflammation give this smear a hypercellular appearance. The polymorphous cellular composition clearly favors a benign reactive process in this case.

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