Antibiotics: Methods and Protocols by Peter Sass (eds.)

By Peter Sass (eds.)

This quantity offers cutting-edge and novel equipment on antibiotic isolation and purification, id of antimicrobial killing mechanisms, and strategies for the research and detection of microbial variation ideas. Antibiotics: equipment and Protocols publications readers via chapters on construction and layout, mode of motion, and reaction and susceptibility. Written within the hugely winning Methods in Molecular Biology series layout, chapters comprise introductions to their respective themes, lists of the mandatory fabrics and reagents, step by step, without problems reproducible laboratory protocols, and pointers on troubleshooting and warding off recognized pitfalls.

Authoritative and state of the art, Antibiotics: equipment and Protocols goals to motivate clinical paintings within the intriguing box of antibiotic research.

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Pelaez F (2006) The historical delivery of antibiotics from microbial natural products—can history repeat? Biochem Pharmacol 71(7):981– 990. 010 2. Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75(3):311– 335. 1021/np200906s 3. Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr, Infectious Diseases Society of America (2008) The epidemic of antibioticresistant infections: a call to action for the medical community from the Infectious Diseases Society of America.

Nat Commun 6:6320 Sass P, Brötz-Oesterhelt H (2013) Bacterial caseinolytic proteases as novel targets for antibacterial treatment. Int J Med Microbiol 304(1):23–30 Baker TA, Sauer RT (2012) ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta 1823(1):15–28 Li DH, Chung YS, Gloyd M, Joseph E, Ghirlando R, Wright GD, Cheng YQ, Maurizi MR, Guarne A, Ortega J (2010) Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP.

Medema MH, Fischbach MA (2015) Computational approaches to natural product discovery. Nat Chem Biol 11(9):639–648. 1884 5. Arnison PG, Bibb MJ, Bierbaum G et al (2013) Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep 30(1):108–160. 1039/c2np20085f 6. Daum M, Herrmann S, Wilkinson B, Bechthold A (2009) Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol 13(2):180–188.

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