Ankylosing spondylitis and Klebsiella by Alan Ebringer

By Alan Ebringer

Ankylosing spondylitis and Klebsiella is a finished and informative textual content at the explanation for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a situation which impacts 20 million humans all over the world and is probably going prompted or initiated via a bowel an infection from Klebsiella bacteria.

When a sufferer is contaminated by means of Klebsiella bacteria, his or her immune approach will make antibodies opposed to the entire antigens or molecules present in the microbe. simply because many of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues akin to the joints and the cells having a similar HLA molecules, that's how the sickness AS starts off. this is often the concept that of molecular similarity or “molecular mimicry” which formerly has been discovered to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.

The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological themes were released, from Prof Ebringer’s staff, on the department of existence Sciences, King’s collage in London, united kingdom.

The correct details from those papers is extracted and offered during this ebook layout making it obtainable to healthiness execs, study associations, pharmaceutical businesses and universities and most of the people.

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05). 11 Discussion and Conclusions The experiments reported here indicate that pregnant women immunised with HLA-B27 lymphocytes produce allogeneic sera that show increased binding for Klebsiella antigens compared to sera produced against non-HLA-B27 antigens (Avakian et al. 1980). 11 41 Discussion and Conclusions % KSP 125I bound 30 20 10 B27(6 sera) Non-B27(388,2812,185) 0 200 400 600 Reciprocal dilotion 800 Fig. 1 Radio-binding assay using 125I-Klebsiella sonicate preparation of monospecific HLA typing sera.

I. London and New York: Academic; 1967. p. 28. Welsh J, Avakian H, Cowling P, Ebringer A, Wooley P, Panayi G, Ebringer R. Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol. 1980;61:85–91. Westphal O, Luderitz O, Bister F. Über die Extraktion von Bakterien mit Phenol/Wasser. Z Naturforsch. 1952;7b:148. 1 Introduction: Molecular Mimicry and Tissue Typing Sera Rabbits immunised with human HLA-B27 lymphocytes have been shown to react against antigens obtained from several Gram-negative microorganisms.

Br J Rheumatol. 1983;27 Suppl 2:1–4. Chem RK, Schmit P, Fauré C. Did Rameses II really have ankylosing spondylitis ? A reappraisal. Can Assoc Radiol J. 2004;55:211–7. Fagge CH. A case of simple synostosis of the ribs to the vertebrae and of the arches and articular processes of the vertebrae themselves and also of one hip joint. Trans Pathol Soc Lond. 1877;28:201–6. References 13 Feldtkeller E, Lemmel EM, Russell AS. Ankylosing spondylitis in the Pharaohs of ancient Egypt. Rheumatol Int. 2003;23:1–5.

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