Adipose Tissue and Adipokines in Health and Disease by Giamila Fantuzzi

By Giamila Fantuzzi

This ebook offers a finished survey of adipose tissue, its physiological services, and its position in affliction. the quantity spans the full diversity of adipose tissue experiences, from uncomplicated anatomical and physiological learn to epidemiology and scientific reports. Groundbreaking fresh reports are included into conventional versions of adipose tissue homes. an outline of the function of macrophages in weight problems and metabolism in integrated.

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Extra resources for Adipose Tissue and Adipokines in Health and Disease (Nutrition & Health)

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The characteristics of the organ can be adapted to functional requirements in relation to the energy balance of the organism. The two tissues seem to derive from precursors with different morphological and functional characteristics, but with possibilities of reciprocal conversion, with an important role played by the nervous system. Both white and brown adipocytes produce factors that can influence the tissue pattern, adapting it to the functional needs. REFERENCES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

J Clin Pathol 2004;57:993–994. qxd 12/12/06 2 12:32 PM Page 21 Metabolism of White Adipose Tissue Michel Beylot Abstract Triacylglycerols (TAGs) stored in adipose tissue are by far the largest site of energy storage. Adipocytes continuously synthesize and break down these TAGs depending on the body energy status and its hormonal environment. They act as a “buffer” for plasma lipids and also for lipids stored in other tissues. This chapter presents the metabolic pathways used for adipose tissue TAG synthesis and breakdown and the way they are controlled.

On this matter, it is interesting to note that human adults with reduced brown phenotype of abdominal subcutaneous adipose tissue have reduced insulin sensitivity and that human white adipocyte precursors can be induced in vitro to express UCP1 by administration of drugs (46). 9. CONCLUSIONS This chapter described in detail the anatomy of adipose tissue and introduced the novel concept of the adipose organ. Both white and brown adipose tissues are organised into a real organ, with a complex multi-depot organisation.

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