Adenoviruses: Model and Vectors in Virus-Host Interactions: by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler,

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the earlier years have noticeable quick growth within the box of adenovirus examine. furthermore, adenoviruses have attracted massive curiosity as vectors in gene move regimens.

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Additional resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

Sample text

Penton plays an essential role in the infection of host cells. 1968; DEVAUX et al. 1987; LOUIS et al. 1994; HENRY et al. 1994). The penton base protein is involved in virus internalization, through direct interaction of an ArgGlyAsp (RGD) sequence, probably localized in the flexible loop region of the penton base, with cell integrins (WICKHAM et al. 1966; STEWART et al. 1997). Fig. 1. Schematic view of adenovirus penton Novel Partner Proteins of Adenovirus Penton 39 2 Primary and Secondary Receptors A closer look at the physical interactions that are necessary for virus attachment to the cell and its internalization, suggests that they are probably not general for all human adenoviruses and most probably not sufficient for the virus infectious cycle.

It appears that the Adenoviridae is the first virus family in which molecular phylogeny is able to reveal a progressive development seemingly compatible with the evolutionary development of the full range of vertebrate hosts. Comprehensive phylogenetic analysis of the family Herpesviridae resulted in much more cautious and prudent conclusions, which concern mainly the present relationships between the members of this huge virus family (MCGEOCH et al. 2000), and no clear hypothesis inferring the direction of development could be elaborated for every subfamily.

Science 283:9981001 HESS M (2000) Detection and differentiation of avian adenoviruses: a review. Avian Patho129:195-206 HESS M, BLOCKER H, BRANDT P (1997) The complete nucleotide sequence of the egg drop syndrome virus: an intermediate between mastadenoviruses and aviadenoviruses. Virology 238: 145-156 Molecular Evolution of Adenoviruses 33 IDAMAKANTI N, REDDY PS, BABIUK LA, TiKOO SK (1999) Transcription mapping and characterization of284R and 121R proteins produced from early region 3 of bovine adenovirus type 3.

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