Acute Liver Failure by William M. Lee, Roger Williams, Jean-Pierre Benhamou,

By William M. Lee, Roger Williams, Jean-Pierre Benhamou, Jacques Bernuau

Acute liver failure (ALF), or fulminant hepatic failure, is a special scientific syndrome that crosses clinical disciplines. a comparatively infrequent , ALF is still a huge concentration of scientific and examine consciousness. With the arrival of transplantation, the significance of realizing administration of ALF has taken on a brand new urgency. during this first quantity devoted to ALF, the editors compile a individual workforce of members to explain the etiology, pathology and remedy of this crucial syndrome. additionally lined are consensus recommendations in liver transplantation for ALF sufferers, in addition to descriptions of man-made and bioartificial liver support units. a piece on destiny remedies contains hepatocyte transplantation, auxiliary grafts and different transitority liver aid. outstanding for the excessive point of the authors' services, this finished quantity should still end up priceless.

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However, in five cases in which electron microscopy was performed by two different groups of investigators (Devaney etal. 1992; Pappoetal. 1994) no viral particles could be found. Some investigators reported finding "giant cells" in patients with liver disease of defined etiology suggesting that since giant cell formation is a common histologic finding in infants with heterogeneous causes of liver disease, such syncytial giant cell formation in adults, while rare, might merely represent a nonspecific pathologic response.

Fungal infection: a common, unrecognised complication of acute liver failure. Hepatology 12:1-9. , Bradley, D. and Williams, R. 1994. Hepatitis C and E in fulminant hepatic failure: a polymerase chain reaction and serological study. JHepatol 20: 580-8. , Yones, A. and Vokota, K. 1990. Cerebrovascular reactivity to CO2 in patients with hepatic or septic encephalopathy. Resuscitation 19: 125—34. , Otto, G. and Goeser, T. 1992. Role of hepatitis C FAILURE virus infection in German patients with fulminant and subacute hepatic failure.

Thus, in most cases the presence of a specific viral infection is strongly suggested by skin rash or mouth ulcers, or the presence of an immunocompromised host. However, in some cases these viral infections have been noted to present with only hepatic manifestations and/or to occur in nonimmunocompromised hosts. 1, virtually all of the Herpesviruses have been implicated as rare causes of acute liver failure although the etiology of cases attributed to cytomegalovirus or Epstein—Barr virus infections has been questioned (Bernuau et al.

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